Potency of Cannabidiol
The potency of Cannabidiol, or any ligand, is a complex interplay between its “ligand efficiency” and its “bioactivity” or binding affinity.
“Ligand efficiency” refers to the ability of the ligand, to produce a biological response of some magnitude. This response may be as an “agonist” (positive response), an “antagonist” (blocks the agonist) or “inverse agonist” (opposite response of the agonist).
CB2, Cannabidiol and Bioactivity
BIOACTIVITY IS THE MEASURE OF THE STRENGTH OF THE BOND BETWEEN THE EPITOPE AND THE MIMOTOPE
Cannabidiol has a functional response within live tissue. In the case of the bioactivity test, the binding affinity, or binding strength of the molecule to the CB2 receptor site is measured.
CB2, cannabinoid receptor type 2, is a G protein-coupled receptor from the endocannabinoid family. This receptor is referred to as the “mimotope”. The antigen, Cannabidiol, has a corresponding site, the “epitope” which binds to the mimotope. The strength of this bond is called “BioActivity of CBD”.